Aftersurvivingtheslaughterofherentiresquadinadrugraidcompromisedbydirtycops,anti-narcoticsspecialoperativeNinaManigan(AnneCurtis),iseagertogohead-to-headwiththedrugcartelsthatholdabloodygriponManila.Butwhenhernewmissioninthecity'smostdangerousslumgoessouth,theangryciviliansturnonhersquad.Trappedbetweenabrutaldruggangandhordesofbloodthirstycitizens,theironlyoptionistofighttheirwayout,turningoneclaustrophobicstreetatatimeintoasymphonyofapocalypticviolence.